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Disgraced financier Bernard Madoff appeared in federal court in New York Thursday and pleaded guilty to running a multibillion dollar Ponzi scheme. The judge denied a request from Madoff's lawyer that he remain free until sentencing in June, sending Madoff to jail.

Pakistan is strongly protesting a U.S. airstrike that it says killed 11 soldiers at a border post. The men were part of the Frontier Corps serving on the Pakistan-Afghanistan border. The incident is straining an already tense relationship between the countries.

Automaker Toyota has announced its first operating loss since 1938. The company cited a severe drop in demand for its cars, especially in the U.S., which accounts for one-third of its vehicle sales. New York Times senior correspondent Micheline Maynard offers her insight.

Tom Daschle withdrew his name from consideration as President Obama's nominee for secretary of health and human services on Tuesday amid questions over his failure to pay more than $140,000 in back taxes.

The questionnaire on the National Cancer Institute's website estimates lifetime risk and five-year risk based on factors known to increase the likelihood of a woman developing breast cancer.

Gianfranco Torres-Navarro, the leader of "Los Killers" who is wanted for 23 killings in Peru, was arrested in Endicott, N.Y. He is being held at a detention facility pending an immigration hearing.

Michael Lacey, a founder of the classified site Backpage.com, was sentenced to five years in prison and fined $3 million in a money laundering case in a case involving allegations of sex trafficking.

Research shows young people are more likely to splurge on treats than older generations, in part due to social media.

California often takes the lead with new legislation to rein in tech. This was true for privacy, social media and now it looks to be playing out the same way for generative AI.

Derrick Johnson, president of the NAACP, says that without an appropriate response from American Airlines, the civil rights organization will be forced to reinstate an advisory against the airline.